Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates

被引：9
|
作者：
Zhang, Yun-Xiao [1 ]
Dai, Gui-Fu [1 ]
Wang, Le [1 ]
Tao, Jing-Chao [1 ]
机构：
[1] Zhengzhou Univ, New Drug Res & Dev Ctr, Dept Chem, Zhengzhou 450052, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期
关键词：
tegafur; fatty acid; conjugates; synthesis; cytotoxicity;
D O I：
10.1016/j.bmcl.2006.12.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N3-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1613 / 1615
页数：3
相关论文
共 50 条
  • [31] Synthesis of nucleoside-amino acid conjugates containing boranephosphate, boranephosphorothioate and boranephosphoramidate linkages
    Baraniak, J
    Kaczmarek, R
    Wasilewska, E
    TETRAHEDRON LETTERS, 2004, 45 (04) : 671 - 675
  • [32] Novel porphyrin-psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies
    Kumar, Dalip
    Mishra, Bhupendra A.
    Shekar, K. P. Chandra
    Kumar, Anil
    Akamatsu, Kanako
    Kurihara, Ryohsuke
    Ito, Takeo
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11 (39) : 6675 - 6679
  • [33] Synthesis, antimicrobial activity and cytotoxicity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues
    Strobykina, Irina Yu
    Voloshina, Alexandra D.
    Andreeva, Olga, V
    Sapunova, Anastasiia S.
    Lyubina, Anna P.
    Amerhanova, Syumbelya K.
    Belenok, Mayya G.
    Saifina, Liliya F.
    Semenov, Vyacheslav E.
    Kataev, Vladimir E.
    BIOORGANIC CHEMISTRY, 2021, 116
  • [34] Synthesis and biological evaluation of novel neamine-nucleoside conjugates potentially targeting to RNAs
    Xu, Yanli
    Jin, Hongwei
    Yang, Zhenjun
    Zhang, Liangren
    Zhang, Lihe
    TETRAHEDRON, 2009, 65 (27) : 5228 - 5239
  • [35] Total synthesis of methotrexate-γ-TRIS-fatty acid conjugates
    Francis, CL
    Yang, Q
    Hart, NK
    Widmer, F
    Manthey, MK
    He-Williams, HM
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2002, 55 (10) : 635 - 645
  • [36] Total synthesis of novel analogs of C-5 curcumin fatty acid conjugates and their potential as anticancer compounds
    Rosario, Joshua
    Abrams, Orlando
    Rios, Camille
    Sanabria-Rios, David
    Rodriguez, Jose W.
    Herrera, Jose
    Altieri-Rivera, Joanne
    Rios-Olivares, Eddy
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [37] Synthesis of novel fatty acid derivatives of Etidronic acid
    Turhanen, PA
    Vepsäläinen, JJ
    SYNTHESIS-STUTTGART, 2005, (18): : 3063 - 3066
  • [38] Novel anticancer nanogel conjugates of activated nucleoside analogs
    Senanayake, Thulani H.
    Warren, Galya
    Vinogradov, Serguei V.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [39] Inhibition of ribonuclease A by nucleoside-dibasic acid conjugates
    Debnath, Joy
    Dasgupta, Swagata
    Pathak, Tanmaya
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (18) : 6491 - 6495
  • [40] Novel Anticancer Polymeric Conjugates of Activated Nucleoside Analogues
    Senanayake, Thulani H.
    Warren, Galya
    Vinogradov, Serguei V.
    BIOCONJUGATE CHEMISTRY, 2011, 22 (10) : 1983 - 1993
12345