Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage

被引：125
|
作者：
Shimohama, S
Greenwald, DL
Shafron, DH
Akaika, A
Maeda, T
Kaneko, S
Kimura, J
Simpkins, CE
Day, AL
Meyer, EM
机构：
[1] Univ Florida, J Hillis Miller Hlth Ctr, Coll Med, Dept Pharmacol, Gainesville, FL 32610 USA
[2] Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan
[3] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA
[4] Kyoto Univ, Fac Pharmaceut Sci, Dept Pharmacol, Kyoto 606, Japan
来源：
BRAIN RESEARCH | 1998年 / 779卷 / 1-2期
关键词：
DMXB; NMDA receptor; neuroprotection; nicotinic; ischemia; mecamylamine;
D O I：
10.1016/S0006-8993(97)00194-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The alpha 7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha 7 receptors appear neuroprotective in non-apoptotic model. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：359 / 363
页数：5
相关论文
共 50 条
  • [31] DOES LIDOFLAZINE PROTECT THE MYOCARDIUM AGAINST ISCHEMIC OR REPERFUSION DAMAGE
    VANDERVUSSE, GJ
    SCHOLS, J
    SNOECKX, L
    FLAMENG, W
    RENEMAN, RS
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1983, 264 (02): : 333 - 333
  • [32] DO BARBITURATES PROTECT AGAINST ISCHEMIC BRAIN-DAMAGE
    不详
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1980, 40 (03): : 199 - 199
  • [33] Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro
    Maragakis, NJ
    Rao, MS
    Llado, J
    Wong, V
    Xue, HP
    Pardo, A
    Herring, J
    Kerr, D
    Coccia, C
    Rothstein, JD
    GLIA, 2005, 50 (02) : 145 - 159
  • [34] Regulation of Glutamate Release by α7 Nicotinic Receptors: Differential Role in Methamphetamine-Induced Damage to Dopaminergic and Serotonergic Terminals
    Northrop, Nicole A.
    Smith, Laura P.
    Yamamoto, Bryan K.
    Eyerman, David J.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 336 (03): : 900 - 907
  • [35] Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia
    Wallace, Tanya L.
    Bertrand, Daniel
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (02) : 139 - 155
  • [36] Properties of neuronal α7 mutant nicotinic acetylcholine receptors gated by bicuculline
    Tonini, R
    Palma, E
    Miledi, R
    Eusebi, F
    NEUROPHARMACOLOGY, 2003, 44 (06) : 765 - 771
  • [37] A monoclonal antibody against HIV Tat attenuates neurotoxicity via glutamate receptors
    Rumbaugh, Jeffrey
    Bachani, Muznabanu
    Tikhonov, Ilia
    Pauza, David
    Nath, Avindra
    RETROVIROLOGY, 2006, 3
  • [38] Mechanisms of nicotinic receptor-mediated neuroprotection by acetylcholinesterase inhibitors against apoptotic glutamate neurotoxicity
    Takada-Takatori, Yuki
    Kume, Toshiaki
    Katsuki, Hiroshi
    Sugimoto, Hachiro
    Akaike, Akinori
    NEUROSCIENCE RESEARCH, 2006, 55 : S101 - S101
  • [39] A monoclonal antibody against HIV Tat attenuates neurotoxicity via glutamate receptors
    Rumbaugh, Jeffrey A.
    Bachani, Muznabanu
    Tikhonov, Ilia
    Pauza, David
    Nath, Avindra
    JOURNAL OF NEUROVIROLOGY, 2006, 12 : 72 - 73
  • [40] A monoclonal antibody against HIV Tat attenuates neurotoxicity via glutamate receptors
    Jeffrey Rumbaugh
    Muznabanu Bachani
    Ilia Tikhonov
    David Pauza
    Avindra Nath
    Retrovirology, 3 (Suppl 1)
12345