Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage

被引：125
|
作者：
Shimohama, S
Greenwald, DL
Shafron, DH
Akaika, A
Maeda, T
Kaneko, S
Kimura, J
Simpkins, CE
Day, AL
Meyer, EM
机构：
[1] Univ Florida, J Hillis Miller Hlth Ctr, Coll Med, Dept Pharmacol, Gainesville, FL 32610 USA
[2] Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan
[3] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA
[4] Kyoto Univ, Fac Pharmaceut Sci, Dept Pharmacol, Kyoto 606, Japan
来源：
BRAIN RESEARCH | 1998年 / 779卷 / 1-2期
关键词：
DMXB; NMDA receptor; neuroprotection; nicotinic; ischemia; mecamylamine;
D O I：
10.1016/S0006-8993(97)00194-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The alpha 7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha 7 receptors appear neuroprotective in non-apoptotic model. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：359 / 363
页数：5
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