Additional pyrrolomycins from cultures of Streptomyces fumanus

被引：17

作者：

Charan, RD ^{[1
]}

Schlingmann, G ^{[1
]}

Bernan, VS ^{[1
]}

Feng, XD ^{[1
]}

Carter, GT ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 02期

关键词：

D O I：

10.1021/np0496542

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin 1 (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chiral members of the pyrrolomycin family of antibiotics, and their absolute stereochemistry was deduced to be 13S. Here, we report the isolation, structure elucidation, and antimicrobial activity of these new pyrrolomycins.

引用

页码：277 / 279

页数：3

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