Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

被引：51
|
作者：
Coyle, N [1 ]
Jones, I [1 ]
Roberson, E [1 ]
Lendon, C [1 ]
Craddock, N [1 ]
机构：
[1] Univ Birmingham, Queen Elizabeth Psychiat Hosp, Div Neurosci, Birmingham B15 2QZ, W Midlands, England
来源：
LANCET | 2000年 / 356卷 / 9240期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0140-6736(00)02877-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important. (population attributable fraction=69%) influence on susceptibility to such episodes.
引用
收藏
页码：1490 / 1491
页数：2
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