Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

被引：51

作者：

Coyle, N ^{[1
]}

Jones, I ^{[1
]}

Roberson, E ^{[1
]}

Lendon, C ^{[1
]}

Craddock, N ^{[1
]}

机构：

[1] Univ Birmingham, Queen Elizabeth Psychiat Hosp, Div Neurosci, Birmingham B15 2QZ, W Midlands, England

来源：

LANCET | 2000年 / 356卷 / 9240期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(00)02877-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important. (population attributable fraction=69%) influence on susceptibility to such episodes.

引用

页码：1490 / 1491

页数：2

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