Asymmetric Synthesis of 2,3-Disubstituted Cyclic Ketones by Enantioselective Conjugate Radical Additions

被引：2
|
作者：
Nad, Sukanya [1 ]
Sibi, Mukund P. [1 ]
机构：
[1] North Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA
来源：
HELVETICA CHIMICA ACTA | 2019年 / 102卷 / 12期
关键词：
enantioselectivity; chiral Lewis acids; radical reactions; conjugate additions; cyclic ketones; ALPHA-AMINO RADICALS; ALPHA; BETA-UNSATURATED KETONES; PHOTOREDOX CATALYSIS; ALKYL RADICALS; ACID; TRANSFORMATIONS; EQUIVALENTS; DERIVATIVES; CYCLIZATION; PENIENONE;
D O I：
10.1002/hlca.201900223
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enantioselective conjugate radical addition to 2-acyloxymethyl cycloalkenones proceeds in high yield with outstanding diastereoselectivity and excellent enantioselectivity using chiral salen Lewis acids. The process provides access to 2,3-disubstituted cycloalkanones, a structural motif present in natural products.
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页数：8
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