Asymmetric Synthesis of 2,3-Disubstituted Cyclic Ketones by Enantioselective Conjugate Radical Additions

被引：2

作者：

Nad, Sukanya ^{[1
]}

Sibi, Mukund P. ^{[1
]}

机构：

[1] North Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA

来源：

HELVETICA CHIMICA ACTA | 2019年 / 102卷 / 12期

关键词：

enantioselectivity; chiral Lewis acids; radical reactions; conjugate additions; cyclic ketones; ALPHA-AMINO RADICALS; ALPHA; BETA-UNSATURATED KETONES; PHOTOREDOX CATALYSIS; ALKYL RADICALS; ACID; TRANSFORMATIONS; EQUIVALENTS; DERIVATIVES; CYCLIZATION; PENIENONE;

D O I：

10.1002/hlca.201900223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective conjugate radical addition to 2-acyloxymethyl cycloalkenones proceeds in high yield with outstanding diastereoselectivity and excellent enantioselectivity using chiral salen Lewis acids. The process provides access to 2,3-disubstituted cycloalkanones, a structural motif present in natural products.

引用

页数：8

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