Efficient syntheses of trans-(+)-laurediol from carbohydrate precursors

被引：8
|
作者：
Gadikota, RR [1 ]
Keller, AI [1 ]
Callam, CS [1 ]
Lowary, TL [1 ]
机构：
[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 06期
关键词：
D O I：
10.1016/S0957-4166(03)00078-8
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two routes for the synthesis of the marine natural product trans-laurediol 6 are described. In the first approach 6 is obtained in ten steps and 21% overall yield from monoacetone D-glucose. The second route provides the target in eleven steps and 13% yield from D-mannose. Both routes are more efficient, both in terms of number of steps and overall yield, than previously reported syntheses. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：737 / 742
页数：6
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