Effect of transforming growth factor-beta 1 and -beta 2 on in vitro rabbit corneal epithelial cell proliferation promoted by epidermal growth factor, keratinocyte growth factor, or hepatocyte growth factor

被引：56
|
作者：
Honma, Y
Nishida, K
Sotozono, C
Kinoshita, S
机构：
[1] Department of Ophthalmology, Kyoto Pref. University of Medicine, Kamigyo-ku, Kyoto 602, Kawaramachi Hirokoji
来源：
EXPERIMENTAL EYE RESEARCH | 1997年 / 65卷 / 03期
关键词：
transforming growth factor-beta 1 (TGF-beta 1); transforming growth factor-beta 2 (TGF-beta 2); epidermal growth factor (EGF); keratinocyte growth factor (KGF); hepatocyte growth factor (HGF); corneal epithelial cell; cell proliferation;
D O I：
10.1006/exer.1997.0338
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Corneal epithelial wound healing is intimately controlled by a variety of growth factors, such as epidermal growth factor (EGF), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and transforming growth factor-beta s (TGF-beta s). In this study, we investigate the effects of TGF-beta 1 and TGF-beta 2 on cultured rabbit corneal epithelial cell proliferation promoted by EGF, KGF, or HGF. Both TGF-beta 1 and -beta 2 dose-dependently inhibited corneal epithelial cell proliferation promoted by KGF (40 ng ml(-1)) and HGF (40 ng ml(-1)), and weakly inhibited cell proliferation promoted by EGF (4 ng ml(-1)). Furthermore, the inhibitory effect tended to be stronger with TGF-beta 2 than TGF-beta 1. These findings suggest that TGF-beta 1 and -beta 2 play important roles as negative modulators against the cell proliferation effect of EGF, KGF and HGF. (C) 1997 Academic Press Limited.
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页码：391 / 396
页数：6
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