The relationship of polyethylene wear to particle size, distribution, and number: A possible factor explaining the risk of osteolysis after hip arthroplasty

The most critical factor in the development of peri-prosthetic osteolysis (OL) in total hip arthroplasty (THA) is the biological reaction to wear debris. This reaction is dependent, in part, on the size and concentration of particles, which are determined predominantly by the polyethylene (PE) wear rate. This implies that the risk for developing OL and prosthesis failure can be estimated from wear measurements. We developed a computational algorithm for calculating the total number of PE particles for volumetric wear when particle size and distribution are known. We found that: (i) total number of PE wear particles decreases up to 5 orders of magnitude if the average size of particles increases and the total volumetric wear remains constant; (ii) total amount of PE wear particles decreases up to 4 orders of magnitude if the width of the distribution increases and total volumetric wear remains constant; (iii) for the same volumetric wear, the number of particles significantly decreases/increases with the increase/decrease in their average size and range. These findings suggest that the risk for the development of OL in THA cannot be simply estimated from the volumetric wear alone. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B:171-177, 2010.