FYN REGULATES MULTIPOLAR-BIPOLAR TRANSITION AND NEURITE MORPHOGENESIS OF MIGRATING NEURONS IN THE DEVELOPING NEOCORTEX

被引：11

作者：

Huang, Yingxue ^{[1
]}

Li, Guohong ^{[1
]}

An, Lei ^{[1
]}

Fan, Yanle ^{[1
]}

Cheng, Xinran ^{[1
]}

Li, Xuzhao ^{[1
]}

Yin, Yupeng ^{[1
]}

Cong, Rihua ^{[1
]}

Chen, Shulin ^{[1
]}

Zhao, Shanting ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Vet Med, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

来源：

NEUROSCIENCE | 2017年 / 352卷

基金：

中国国家自然科学基金;

关键词：

Fyn; RNAi; in utero electroporation; neuronal migration; DEVELOPING CEREBRAL-CORTEX; INSIDE-OUT LAMINATION; BRAIN-DEVELOPMENT; RADIAL MIGRATION; CELL-MIGRATION; MICROTUBULE ORGANIZATION; CORTICAL LAMINATION; SIGNALING PATHWAY; TYROSINE-KINASE; GENE-TRANSFER;

D O I：

10.1016/j.neuroscience.2017.03.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fyn is a non-receptor protein tyrosine kinase that belongs to Src family kinases. Fyn plays a critical role in neuronal migration, but the mechanism remains unclear. Here, we reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons. Morphological analysis showed that loss of Fyn function impaired multipolar-bipolar transition of newly generated neurons and neurite formation in the early phase of migration. Moreover, Fyn inhibition increased the length of leading process and decreased the branching number of the migrating cortical neurons. Together, these results indicate that Fyn controls neuronal migration by regulating the cytoskeletal dynamics and multipolar-bipolar transition of newly generated neurons during cortical development. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：39 / 51

页数：13

共 37 条

[31] Endogenous erythropoietin signaling regulates migration and laminar positioning of upper-layer neurons in the developing neocortex
Constanthin, Paul E.
Contestabile, Alessandro
Petrenko, Volodymyr
Quairiaux, Charles
Salmon, Patrick
Hueppi, Petra S.
Kiss, Jozsef Z.
DEVELOPMENT, 2020, 147 (19):
[32] Rabex-5 Protein Regulates Dendritic Localization of Small GTPase Rab17 and Neurite Morphogenesis in Hippocampal Neurons
Mori, Yasunori
Matsui, Takahide
Fukuda, Mitsunori
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (14) : 9835 - 9847
[33] C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development
Shah, Bhavin
Lutter, Daniela
Bochenek, Magdalena L.
Kato, Katsuhiro
Tsytsyura, Yaroslav
Glyvuk, Natalia
Sakakibara, Akira
Klingauf, Juergen
Adams, Ralf H.
Pueschel, Andreas W.
PLOS ONE, 2016, 11 (04):
[34] MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex
Bian, Shan
Hong, Janet
Li, Qingsong
Schebelle, Laura
Pollock, Andrew
Knauss, Jennifer L.
Garg, Vidur
Sun, Tao
CELL REPORTS, 2013, 3 (05): : 1398 - 1406
[35] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
Ohshima, Toshio
Hirasawa, Motoyuki
Tabata, Hidenori
Mutoh, Tetsuji
Adachi, Tomoko
Suzuki, Hiromi
Saruta, Keiko
Iwasato, Takuji
Itohara, Shigeyoshi
Hashimoto, Mistuhiro
Nakajima, Kazunori
Ogawa, Masaharu
Kulkarni, Ashok B.
Mikoshiba, Katsuhiko
DEVELOPMENT, 2007, 134 (12): : 2273 - 2282
[36] Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons
Cohen, Matthew R.
Johnson, William M.
Pilat, Jennifer M.
Kiselar, Janna
DeFrancesco-Lisowitz, Alicia
Zigmond, Richard E.
Moiseenkova-Bell, Vera Y.
MOLECULAR AND CELLULAR BIOLOGY, 2015, 35 (24) : 4238 - 4252
[37] Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP)-43 mRNA through the ALK/GSK3β/β-catenin signaling in developing mouse neurons
Yanagisawa, Hiroko
Komuta, Yukari
Kawano, Hitoshi
Toyoda, Masashi
Sango, Kazunori
NEUROSCIENCE RESEARCH, 2010, 66 (01) : 111 - 116

← 1 2 3 4 →