FYN REGULATES MULTIPOLAR-BIPOLAR TRANSITION AND NEURITE MORPHOGENESIS OF MIGRATING NEURONS IN THE DEVELOPING NEOCORTEX

被引：11
|
作者：
Huang, Yingxue [1 ]
Li, Guohong [1 ]
An, Lei [1 ]
Fan, Yanle [1 ]
Cheng, Xinran [1 ]
Li, Xuzhao [1 ]
Yin, Yupeng [1 ]
Cong, Rihua [1 ]
Chen, Shulin [1 ]
Zhao, Shanting [1 ]
机构：
[1] Northwest A&F Univ, Coll Vet Med, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
来源：
NEUROSCIENCE | 2017年 / 352卷
基金：
中国国家自然科学基金;
关键词：
Fyn; RNAi; in utero electroporation; neuronal migration; DEVELOPING CEREBRAL-CORTEX; INSIDE-OUT LAMINATION; BRAIN-DEVELOPMENT; RADIAL MIGRATION; CELL-MIGRATION; MICROTUBULE ORGANIZATION; CORTICAL LAMINATION; SIGNALING PATHWAY; TYROSINE-KINASE; GENE-TRANSFER;
D O I：
10.1016/j.neuroscience.2017.03.032
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Fyn is a non-receptor protein tyrosine kinase that belongs to Src family kinases. Fyn plays a critical role in neuronal migration, but the mechanism remains unclear. Here, we reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons. Morphological analysis showed that loss of Fyn function impaired multipolar-bipolar transition of newly generated neurons and neurite formation in the early phase of migration. Moreover, Fyn inhibition increased the length of leading process and decreased the branching number of the migrating cortical neurons. Together, these results indicate that Fyn controls neuronal migration by regulating the cytoskeletal dynamics and multipolar-bipolar transition of newly generated neurons during cortical development. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：39 / 51
页数：13
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