Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

被引：16
|
作者：
Kim, Chung Sub [1 ]
Subedi, Lalita [2 ,3 ]
Kwon, Oh Kil [1 ]
Kim, Sun Yeou [2 ,3 ]
Yeo, Eui-Ju [4 ]
Choi, Sang Un [5 ]
Lee, Kang Ro [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea
[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon 21936, South Korea
[3] Gachon Univ, Coll Pharm, Inchon 21936, South Korea
[4] Gachon Univ, Coll Med, Dept Biochem, Inchon 51936, South Korea
[5] Korea Res Inst Chem Technol, Daejeon 34114, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Chaenomeles sinensis; Biphenyl compounds; Cytotoxicity; Anti-inflammation; NGF-potentiation; SORBUS-AUCUPARIA; IN-VITRO; FRUITS; PHYTOALEXINS; SAPWOOD;
D O I：
10.1016/j.bmcl.2015.12.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：351 / 354
页数：4
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