A practical preparation of 5-(ketoaryl)thiazoles

被引：35
|
作者：
Marcantonio, KM [1 ]
Frey, LF [1 ]
Murry, JA [1 ]
Chen, CY [1 ]
机构：
[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 49期
关键词：
D O I：
10.1016/S0040-4039(02)02230-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This article describes a facile synthesis of 2-substituted-5-(ketoaryl)thiazoles, which are important intermediates for the synthesis of biologically active compounds. A variety of 2-substituted thiazole anions were added to aryl nitriles to provide the desired ketones after aqueous hydrolysis. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：8845 / 8848
页数：4
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