Preparation of oligodeoxynucleotides containing 5-(N-methylpiperazinyl) and 5-benzyloxymethyl uracils

被引：0
|
作者：
Megied, AESA [1 ]
Ali, OM
Kofoed, T
Pedersen, EB
机构：
[1] Menoufia Univ, Fac Sci, Dept Chem, Shebien El Koam, Egypt
[2] Odense Univ, Dept Chem, DK-5230 Odense M, Denmark
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 1-2期
关键词：
nucleosides; 5 '-O-DMT nucleosides; nucleoside-3 '-phosphoramidites; oligodeoxynucleotide;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Deprotected compounds 1 and 9 were allowed to react with 4,4'-dimethoxytrityl chloride in pyridine to give 5'-O-DMT nucleosides 2 and 10. The 3'-phosphoramidites 4 and 11 were incorporated into oligodeoxynucleosides (ODNs). The hybridization properties of the modified ODNs with their complementary DNA strands were studied. Interesting results were obtained when 11 was inserted as a bulged nucleoside into TWAs, duplexes, and triplexes.
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页码：1 / 9
页数：9
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