Pd-catalyzed allylic substitution using nucleophilic N-heterocyclic carbene as a ligand

被引：52
|
作者：
Sato, Y [1 ]
Yoshino, T [1 ]
Mori, M [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 01期
关键词：
D O I：
10.1021/ol026961v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nucleophilic N-heterocyclic carbene has been successfully used in a Pd(0)-catalyzed allylic substitution for the first time. It was found that allylic substitution with a soft nucleophile using a Pd-carbene catalyst proceeds via retention of configuration, the stereochemical reaction pathway being the same as that of the reaction using a Pd-phosphine complex.
引用
收藏
页码：31 / 33
页数：3
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