Pd-catalyzed allylic substitution using nucleophilic N-heterocyclic carbene as a ligand

被引：52

作者：

Sato, Y ^{[1
]}

Yoshino, T ^{[1
]}

Mori, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 01期

关键词：

D O I：

10.1021/ol026961v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nucleophilic N-heterocyclic carbene has been successfully used in a Pd(0)-catalyzed allylic substitution for the first time. It was found that allylic substitution with a soft nucleophile using a Pd-carbene catalyst proceeds via retention of configuration, the stereochemical reaction pathway being the same as that of the reaction using a Pd-phosphine complex.

引用

页码：31 / 33

页数：3

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