Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses

被引：23
|
作者：
Kumar, Rahul [1 ,2 ]
Mishra, Sahil [1 ]
Shreya [1 ]
Maurya, Sushil K. [1 ,2 ]
机构：
[1] CSIR Inst Himalayan Bioresource Technol, Chem Technol Div, Palampur 176061, Himachal Prades, India
[2] CSIR HRDC, Acad Sci & Innovat Res, Ghaziabad 201002, Uttar Pradesh, India
来源：
RSC MEDICINAL CHEMISTRY | 2021年 / 12卷 / 03期
关键词：
NONNUCLEOSIDE INHIBITORS; NS5B POLYMERASE; ALLOSTERIC INHIBITORS; ANTIVIRAL ACTIVITY; FAVIPIRAVIR T-705; DESIGN; IDENTIFICATION; CORONAVIRUS; ANALOGS; REPLICATION;
D O I：
10.1039/d0md00318b
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
WHO has declared COVID-19 a pandemic, which has affected the whole world and has caused unprecedented social and economic disruption. Since the emergence of the disease, several druggable targets have been suggested including 3-chymotrypsin-like protease (3CL(pro)), spike, RNA-dependent RNA polymerase (RdRp), and the papain-like protease (PLpro) computational approach. From the beginning, viral replication has been the main focus for any antiviral drug development for viral diseases, including HCV, influenza virus, zika virus, norovirus, measles, dengue virus, and coronaviruses. This review lists the nucleoside, nucleotide, and non-nucleoside RdRp inhibitor analogues of various viral diseases that may be evaluated for drug development to treat COVID-19.
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页码：306 / 320
页数：15
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