Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2

被引：14

作者：

Bekheit, Mohamed S. ^{[1
]}

Panda, Siva S. ^{[2
]}

Girgis, Adel S. ^{[1
]}

机构：

[1] Natl Res Ctr, Dept Pesticide Chem, Giza 12622, Egypt

[2] Augusta Univ, Dept Chem & Phys, Augusta, GA 30912 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 252卷

关键词：

Polymerase; RdRp; SARS-CoV-2; COVID-19; Remdesivir; Favipiravir; Molnupiravir; Computational studies; SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) para; ANTIVIRAL ACTIVITY; DISEASE OUTBREAK; NATURAL-PRODUCTS; EBOLA-VIRUS; IN-VITRO; COVID-19; RIBAVIRIN;

D O I：

10.1016/j.ejmech.2023.115292

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of the key enzymes that control viral replication. RdRp is an attractive and promising therapeutic target for the treatment of SARS-CoV-2 disease. It has attracted much interest of medicinal chemists, especially after the approval of Remdesivir. This study highlights the most promising SARS-CoV-2 RdRp repurposed drugs in addition to natural and synthetic agents. Although many in silico predicted agents have been developed, the lack of in vitro and in vivo experimental data has hindered their application in drug discovery programs.

引用

页数：20

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