Application of [hmim][BF4] ionic liquid in reversed-phase simulated moving bed for the separation of 3-and 4-hydroxybenzoic acid

被引：2
|
作者：
Le, Thai-Hoang [1 ,2 ]
Lee, Ju Weon [3 ]
Kim, Jeung Kun [3 ]
Koo, Yoon-Mo [1 ,3 ]
机构：
[1] Inha Univ, Dept Biol Engn, Inchon, South Korea
[2] Inha Univ, Dept Chem Engn, Inchon, South Korea
[3] Ctr Adv Bioseparat Technol, Inchon, South Korea
来源：
KOREAN JOURNAL OF CHEMICAL ENGINEERING | 2009年 / 26卷 / 05期
关键词：
Ionic Liquid; Ionized Compounds; Mobile Phase Additive; Reversed-phase; Simulated Moving Bed; Continuous Chromatography; CHROMATOGRAPHY; RETENTION; ADDITIVES; PH;
D O I：
10.1007/s11814-009-0210-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In reversed-phase liquid chromatography (RP-LC), the separation of ionized compounds at neutral pH of the mobile phase is ineffective because these compounds easily become ionized and too hydrophilic to adsorb on the hydrophobic C18 stationary phase. The common method to separate ionized compounds in RP-LC is the usage of the ion pairing agent and the control of pH in the mobile phase. In this work, [hmim][BF4] ionic liquid was adopted as a mobile phase additive in reversed-phase simulated moving bed chromatography (RP-SMB) to overcome the problem mentioned above. The results showed that when 1.5 ml/l [hmim][BF4] was added to mobile phase, 3-hydroxy benzoic acid (3-HBA) and 4-hydroxy benzoic acid (4-HBA) were separated at neutral pH in the RP-SMB. In particular, purities of 3-HBA and 4-HBA products were 97.62% and 100%, respectively, and had a good agreement with simulation results.
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页码：1334 / 1340
页数：7
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