The role of miRNAs in colorectal cancer progression and chemoradiotherapy

被引：106
|
作者：
Zhang, Ning [3 ]
Hu, Xianyu [3 ]
Du, Yinan [3 ]
Du, Juan [1 ,2 ,3 ]
机构：
[1] Chinese Univ Hong Kong, Longgang Dist Peoples Hosp Shenzhen, Shenzhen 518172, Guangdong, Peoples R China
[2] Chinese Univ Hong Kong, Affiliated Hosp Provis 3, Shenzhen 518172, Guangdong, Peoples R China
[3] Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 134卷
基金：
中国国家自然科学基金;
关键词：
microRNA; Colorectal cancer; Chemoradiotherapy; Cancer therapy; Biomarkers; COLON-CANCER; CELL-PROLIFERATION; SIGNALING PATHWAY; DOWN-REGULATION; TUMOR-GROWTH; MESENCHYMAL TRANSITION; INHIBITS PROLIFERATION; TRANSCRIPTION FACTORS; RADIATION-RESISTANCE; TARGETING ZEB1;
D O I：
10.1016/j.biopha.2020.111099
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth most deadly cancer worldwide. CRC accounts for approximately 10 % of all new cancer cases globally, remaining the second most frequent cause of cancer-related deaths. MicroRNAs (miRNAs) are a class of small noncoding RNAs that can affect a variety of cellular and molecular targets. Depending on the cell environment in which the information is expressed, miRNAs can serve as a CRC suppressor or promoter and play essential roles in several biological processes. In this review, we summarized the relationship between miRNAs and proliferation, metastasis, angiogenesis, autophagy, apoptosis, and the chemoradiotherapy of CRC, revealing that relevant miRNAs could serve as potential targets for CRC therapy.
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页数：10
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