Progress towards the total synthesis of trichodermamides A and B:: Construction of the oxazine ring moiety

被引：25
|
作者：
Wan, Xiaobo [1 ]
Doridot, Gabriel [1 ]
Joullie, Madeleine M. [1 ]
机构：
[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 06期
关键词：
D O I：
10.1021/ol062993x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Trichodermamides are modified heterocyclic dipeptides that possess a unique 4H-5,6-dihydro-1,2-oxazine ring. Starting from affordable, easily available (-)-quinic acid, the enantioselective synthesis of this oxazine moiety was achieved by an intramolecular epoxide ring-opening reaction by an oxime.
引用
收藏
页码：977 / 980
页数：4
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