New trifluoromethyl-substituted heterocycles by multicomponent reactions of siloxycyclopropanes

被引：4

作者：

Gladow, Daniel ^{[1
]}

Senf, Deborah ^{[1
]}

Wiecko, Jelena ^{[1
]}

Lentz, Dieter ^{[1
]}

Zimmer, Reinhold ^{[1
]}

Reissig, Hans-Ulrich ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, 3 Takustr, D-14195 Berlin, Germany

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 04期

关键词：

amino acids; cyclopropanes; isonitriles; gamma-lactams; pyridines; multicomponent reactions; DONOR-ACCEPTOR CYCLOPROPANES; 4-COMPONENT REACTION; AMINO-ACIDS; 3-COMPONENT CONDENSATION; ORGANIC-SYNTHESIS; UGI; 5-CENTER; DERIVATIVES; CHEMISTRY; ISOCYANIDES; ALDEHYDES;

D O I：

10.1007/s10593-017-2068-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions of ethyl 1-trifluoromethyl-2-(trimethylsilyloxy)cyclopropanecarboxylate, isonitriles, and either 2-aminopyridine or amino acids provided imidazo[1,2-a]pyridines or gamma-lactams, respectively. This access to trifluoromethyl-substituted heterocycles demonstrates again that siloxycyclopropanes can serve as hidden functionalized aldehydes and that this type of donor-acceptor-substituted cyclopropanes is particularly versatile.

引用

页码：416 / 421

页数：6

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