New trifluoromethyl-substituted heterocycles by multicomponent reactions of siloxycyclopropanes

被引：4
|
作者：
Gladow, Daniel [1 ]
Senf, Deborah [1 ]
Wiecko, Jelena [1 ]
Lentz, Dieter [1 ]
Zimmer, Reinhold [1 ]
Reissig, Hans-Ulrich [1 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, 3 Takustr, D-14195 Berlin, Germany
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 04期
关键词：
amino acids; cyclopropanes; isonitriles; gamma-lactams; pyridines; multicomponent reactions; DONOR-ACCEPTOR CYCLOPROPANES; 4-COMPONENT REACTION; AMINO-ACIDS; 3-COMPONENT CONDENSATION; ORGANIC-SYNTHESIS; UGI; 5-CENTER; DERIVATIVES; CHEMISTRY; ISOCYANIDES; ALDEHYDES;
D O I：
10.1007/s10593-017-2068-y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multicomponent reactions of ethyl 1-trifluoromethyl-2-(trimethylsilyloxy)cyclopropanecarboxylate, isonitriles, and either 2-aminopyridine or amino acids provided imidazo[1,2-a]pyridines or gamma-lactams, respectively. This access to trifluoromethyl-substituted heterocycles demonstrates again that siloxycyclopropanes can serve as hidden functionalized aldehydes and that this type of donor-acceptor-substituted cyclopropanes is particularly versatile.
引用
收藏
页码：416 / 421
页数：6
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