Organozirconium-mediated solution- and solid-phase synthesis of 3-benzyl pyrrolidines and other potentially neuroactive amines

被引：11
|
作者：
Hunter, Rupert A. [1 ]
Macfarlane, Donald P. S. [1 ]
Whitby, Richard J. [1 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
来源：
SYNLETT | 2006年 / 19期
关键词：
zirconium; neuroactive; pyrrolidine; solid-phase; library;
D O I：
10.1055/s-2006-951553
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient route to 3-benzylpyrrolidines using a zirconium-mediated cyclisation both in solution and on a solid support is reported. 3-Benzylidine-pyrrolidines, 3 -aryl-pyrrolidines and 4-arylpiperidines were also synthesised.
引用
收藏
页码：3314 / 3318
页数：5
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