Synthesis and biological activity of kappa opioid receptor agonists.: Part 2:: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

被引：37
|
作者：
Semple, G
Andersson, BM
Chhajlani, V
Georgsson, J
Johansson, MJ
Rosenquist, Å
Swanson, L
机构：
[1] AstraZeneca R&D, Dept Med Chem, S-43183 Molndal, Sweden
[2] AstraZeneca R&D, Dept Biochem & Cell Biol, S-43183 Molndal, Sweden
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(03)00033-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1141 / 1145
页数：5
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