Conformational control on remote stereochemistry in the intramolecular Pauson-Khand reactions of enynes tethered to homoallyl and homopropargyl alcohols

被引：10
|
作者：
Sezer, Serdar
Ozdemirhan, Devrim
Sahin, Ertan
Tanyeli, Cihangir [1 ]
机构：
[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey
[2] Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey
[3] Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 21期
关键词：
D O I：
10.1016/j.tetasy.2006.11.012
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An intramolecular Pauson-Khand reaction of enynes derived from homoallyl and homopropargyl alcohols is described. 2-Furyl substituted homoallyl and homopropargyl alcohols are easily and efficiently resolved through enzymatic resolution in a high ee (93-99%) with a known stereochemistry. Each enantiomerically enriched enyne affords the conformationally most stable diastereomeric cyclopenta[c]pyran ring system. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2981 / 2986
页数：6
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