Preparation and Characterization of Size-Controlled Nanoparticles for High-Loading λ-Cyhalothrin Delivery through Flash Nanoprecipitation

被引：39

作者：

Chen, Kai ^{[1
,2
]}

Fu, Zhinan ^{[1
]}

Wang, Mingwei ^{[1
]}

Lv, Yin ^{[2
]}

Wang, Chunxin ^{[3
]}

Shen, Yue ^{[3
]}

Wang, Yan ^{[3
]}

Cui, Haixin ^{[3
]}

Guo, Xuhong ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

[2] Shihezi Univ, Sch Chem & Chem Engn, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Shihezi 832000, Peoples R China

[3] Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 31期

基金：

中国国家自然科学基金;

关键词：

flash nanoprecipitation; nanosuspension; lambda-cyhalothrin; block polymer; COPOLYMER; PROTECTION; EXPOSURE;

D O I：

10.1021/acs.jafc.8b02851

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of lambda-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEGPDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.

引用

页码：8246 / 8252

页数：7

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