Preparation and Characterization of Size-Controlled Nanoparticles for High-Loading λ-Cyhalothrin Delivery through Flash Nanoprecipitation

被引：39
|
作者：
Chen, Kai [1 ,2 ]
Fu, Zhinan [1 ]
Wang, Mingwei [1 ]
Lv, Yin [2 ]
Wang, Chunxin [3 ]
Shen, Yue [3 ]
Wang, Yan [3 ]
Cui, Haixin [3 ]
Guo, Xuhong [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China
[2] Shihezi Univ, Sch Chem & Chem Engn, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Shihezi 832000, Peoples R China
[3] Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 31期
基金：
中国国家自然科学基金;
关键词：
flash nanoprecipitation; nanosuspension; lambda-cyhalothrin; block polymer; COPOLYMER; PROTECTION; EXPOSURE;
D O I：
10.1021/acs.jafc.8b02851
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of lambda-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEGPDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.
引用
收藏
页码：8246 / 8252
页数：7
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