A Mild Protocol foor the Efficient Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridines

被引：19
|
作者：
Maiti, Swarupanada [1 ]
Menendez, J. Carlos [1 ]
机构：
[1] Univ Complutense Madrid, Fac Farm, Dept Quim Organ & Farmaceut, Madrid 28040, Spain
来源：
SYNLETT | 2009年 / 14期
关键词：
eliminations; heterocycles; dihydropryidines; cerium(IV); Lewis acids; 3-COMPONENT DOMINO SYNTHESIS; CHEMICAL DELIVERY-SYSTEMS; MULTIDRUG-RESISTANCE; SUBSTITUTED 1,4-DIHYDROPYRIDINES; PRIVILEGED STRUCTURES; MEDICINAL CHEMISTRY; TETRAHYDROQUINOLINE SYSTEMS; MULTICOMPONENT REACTIONS; 4+2 CYCLOADDITIONS; HANTZSCH REACTION;
D O I：
10.1055/s-0029-1217719
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of 6-alkoxy-1,4,5,6-tetrahydropyridines with neutral alumina (activity grade I) suspended in refluxing aceto-nitrile, afforded 1,4-dihydropyridines in excellent yields. This method allowed the efficient synthesis of 5,6-unsubstituted dihydropyridines, which are difficult to prepare by traditional methods, from acyclic and readily available precursors.
引用
收藏
页码：2249 / 2252
页数：4
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