SYNTHESIS OF METHYL ESTERS OF 5-AROYL-6-ARYL-2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACIDS

被引：5

作者：

Gein, V. L. ^{[1
]}

Krylova, I. V. ^{[2
]}

Tsypliakova, E. P. ^{[1
]}

Gaifullina, A. R. ^{[1
]}

Varkentin, L. I. ^{[1
]}

Vakhrin, M. I. ^{[1
]}

机构：

[1] Perm State Pharmaceut Acad, Perm 614990, Russia

[2] Perm State Med Acad, Perm 614000, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 07期

关键词：

hydrazine hydrate; 8-hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]-pyridazin-2(1H)-one; substituted benzaldehydes; methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids; urea; esters of aroylpyruvic acids;

D O I：

10.1007/s10593-009-0353-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids were synthesized from three component mixtures of methyl esters of aroylpyruvic acids, urea, and substituted benzaldehydes. 8-Hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]pyridazin-2( 1H)-one was synthesized by the reaction of 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidin-4-carboxylate with hydrazine hydrate.

引用

页码：829 / 832

页数：4

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