SYNTHESIS OF METHYL ESTERS OF 5-AROYL-6-ARYL-2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACIDS

被引：5
|
作者：
Gein, V. L. [1 ]
Krylova, I. V. [2 ]
Tsypliakova, E. P. [1 ]
Gaifullina, A. R. [1 ]
Varkentin, L. I. [1 ]
Vakhrin, M. I. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] Perm State Med Acad, Perm 614000, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 07期
关键词：
hydrazine hydrate; 8-hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]-pyridazin-2(1H)-one; substituted benzaldehydes; methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids; urea; esters of aroylpyruvic acids;
D O I：
10.1007/s10593-009-0353-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids were synthesized from three component mixtures of methyl esters of aroylpyruvic acids, urea, and substituted benzaldehydes. 8-Hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]pyridazin-2( 1H)-one was synthesized by the reaction of 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidin-4-carboxylate with hydrazine hydrate.
引用
收藏
页码：829 / 832
页数：4
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