Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

被引：6

作者：

Caruso, Vanni ^{[1
,2
]}

Zuccarini, Mariachiara ^{[3
,4
]}

Di Iorio, Patrizia ^{[3
,4
]}

Muhammad, Ishaq ^{[1
]}

Ronci, Maurizio ^{[4
,5
]}

机构：

[1] Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas, Australia

[2] ISAL Fdn, Inst Res Pain, Rimini, Italy

[3] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy

[4] Univ G dAnnunzio, Ctr Adv Studies & Technol CAST, Chieti, Italy

[5] Univ G dAnnunzio, Dept Pharm, Chieti, Italy

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

purinergic receptors; food intake; metabolic homeostasis; orexigen and anorexigen neurons; obesity; RAT NUCLEUS-ACCUMBENS; ADIPOSE-TISSUE; ADENOSINE RECEPTORS; ENERGY HOMEOSTASIS; DOPAMINE RELEASE; FEEDING-BEHAVIOR; STROMAL CELLS; OBESITY; ATP; NEURONS;

D O I：

10.3389/fphar.2021.655989

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.

引用

页数：7

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