Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

被引：6
|
作者：
Caruso, Vanni [1 ,2 ]
Zuccarini, Mariachiara [3 ,4 ]
Di Iorio, Patrizia [3 ,4 ]
Muhammad, Ishaq [1 ]
Ronci, Maurizio [4 ,5 ]
机构：
[1] Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas, Australia
[2] ISAL Fdn, Inst Res Pain, Rimini, Italy
[3] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy
[4] Univ G dAnnunzio, Ctr Adv Studies & Technol CAST, Chieti, Italy
[5] Univ G dAnnunzio, Dept Pharm, Chieti, Italy
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
关键词：
purinergic receptors; food intake; metabolic homeostasis; orexigen and anorexigen neurons; obesity; RAT NUCLEUS-ACCUMBENS; ADIPOSE-TISSUE; ADENOSINE RECEPTORS; ENERGY HOMEOSTASIS; DOPAMINE RELEASE; FEEDING-BEHAVIOR; STROMAL CELLS; OBESITY; ATP; NEURONS;
D O I：
10.3389/fphar.2021.655989
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] Complement-induced hemolysis and purinergic signaling
    Hejl, Julie Loeye
    Skals, Marianne
    Leipziger, Jens
    Praetorius, Helle A.
    FASEB JOURNAL, 2011, 25
  • [32] Increased food intake induced in rats by changes in the satiating sensory input from food
    le Magnen, J
    APPETITE, 1999, 33 (01) : 33 - 35
  • [33] Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement
    Zhichao Zhou
    Oana Sorop
    Vincent J. de Beer
    Ilkka Heinonen
    Caroline Cheng
    A. H. Jan Danser
    Dirk J. Duncker
    Daphne Merkus
    Purinergic Signalling, 2017, 13 : 319 - 329
  • [34] Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    Airu S. Chen
    Joseph M. Metzger
    Myrna E. Trumbauer
    Xiao-ming Guan
    Hong Yu
    Easter G. Frazier
    Donald J. Marsh
    Michael J. Forrest
    Shobhna Gopal-Truter
    Jill Fisher
    Ramon E. Camacho
    Alison M. Strack
    Theodore N. Mellin
    D. Euan MacIntyre
    Howard Y. Chen
    Lex H.T. Van der Ploeg
    Transgenic Research, 2000, 9 : 145 - 154
  • [35] Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    Chen, AS
    Metzger, JM
    Trumbauer, ME
    Guan, XM
    Yu, H
    Frazier, EG
    Marsh, DJ
    Forrest, MJ
    Gopal-Truter, S
    Fisher, J
    Camacho, RE
    Strack, AM
    Mellin, TN
    MacIntyre, DE
    Chen, HY
    Van der Ploeg, LHT
    TRANSGENIC RESEARCH, 2000, 9 (02) : 145 - 154
  • [36] Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement
    Zhou, Zhichao
    Sorop, Oana
    de Beer, Vincent J.
    Heinonen, Ilkka
    Cheng, Caroline
    Danser, A. H. Jan
    Duncker, Dirk J.
    Merkus, Daphne
    PURINERGIC SIGNALLING, 2017, 13 (03) : 319 - 329
  • [37] Pesticide-induced metabolic changes are amplified by food stress
    Shahid, Naeem
    Rolle-Kampczyk, Ulrike
    Siddique, Ayesha
    von Bergen, Martin
    Liess, Matthias
    SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 792
  • [38] CHANGES IN FOOD + WATER INTAKE INDUCED BY HEATING + COOLING OF PREOPTIC AREA
    SPECTOR, NH
    HAMILTON, CL
    BROBECK, JR
    FEDERATION PROCEEDINGS, 1967, 26 (02) : 555 - &
  • [39] Role of astroglial purinergic signaling in Alzheimer's disease
    Reichenbach, N.
    Petzold, G. C.
    PURINERGIC SIGNALLING, 2018, 14 : S74 - S75
  • [40] Role of purinergic signaling in human and experimental Chagas disease
    Pilar Aoki, Maria
    PURINERGIC SIGNALLING, 2018, 14 : S5 - S6
12345