Synthesis of P-chiral enephosphonic acid derivatives

被引：8

作者：

Grison, C ^{[1
]}

Comoy, C ^{[1
]}

Chatenet, D ^{[1
]}

Coutrot, P ^{[1
]}

机构：

[1] Univ Henri Poincare Nancy 1, CNRS, Inst Nanceien Chim Mol, Lab Chim Organ Biomol,FR 1742,UMR 7565, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2002年 / 662卷 / 1-2期

关键词：

alkylidenediphosphorylation; Horner reaction; diphosphorylated carbanions; P-31-NMR study; Chiral enephosphorylated derivatives;

D O I：

10.1016/S0022-328X(02)01889-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient and convenient synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidenediphosphorylation of nucleophiles followed by a Horner-Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a two-step reaction sequence. Regioselectivity of Horner-Emmons reaction and P-31-NMR study of diphosphorylated anions were described. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：83 / 97

页数：15

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