Synthesis of P-chiral enephosphonic acid derivatives

被引：8
|
作者：
Grison, C [1 ]
Comoy, C [1 ]
Chatenet, D [1 ]
Coutrot, P [1 ]
机构：
[1] Univ Henri Poincare Nancy 1, CNRS, Inst Nanceien Chim Mol, Lab Chim Organ Biomol,FR 1742,UMR 7565, F-54506 Vandoeuvre Les Nancy, France
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2002年 / 662卷 / 1-2期
关键词：
alkylidenediphosphorylation; Horner reaction; diphosphorylated carbanions; P-31-NMR study; Chiral enephosphorylated derivatives;
D O I：
10.1016/S0022-328X(02)01889-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient and convenient synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidenediphosphorylation of nucleophiles followed by a Horner-Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a two-step reaction sequence. Regioselectivity of Horner-Emmons reaction and P-31-NMR study of diphosphorylated anions were described. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：83 / 97
页数：15
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