Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling

被引：61

作者：

Kang, Fu-An ^{[1
]}

Lanter, James C. ^{[1
]}

Cai, Chaozhong ^{[1
]}

Sui, Zhihua ^{[1
]}

Murray, William V. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Spring House, PA 19477 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 08期

关键词：

ARYL BOND FORMATION; C-H; DIRECT ARYLATION; ARYLBORONIC ACIDS; PROTECTING-GROUP; BORONIC ACIDS; ACTIVATION; ARENESULFONATES; ARENES;

D O I：

10.1039/b917777a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C-OH bond activations with direct C(sp(2))-C(sp) bond formation, which is in line with ideal synthesis using readily available materials.

引用

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页码：1347 / 1349

页数：3

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