Palladium-Catalyzed Oxidative Cross-Coupling between Heterocycles and Terminal Alkynes with Low Catalyst Loading

被引：123
|
作者：
Jie, Xiaoming [1 ]
Shang, Yaping [1 ]
Hu, Peng [1 ]
Su, Weiping [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Struct Chem, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 13期
关键词：
CH functionalization; cross-coupling; heterocycles; palladium; terminal alkynes; H BOND ARYLATION; DIRECT ALKYNYLATION; EFFICIENT SYNTHESIS; N-TOSYLHYDRAZONES; GENERAL-METHOD; COPPER; ARYL; THIOPHENES; INDOLES; ACTIVATION;
D O I：
10.1002/anie.201210013
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct: With [Pd2(dba)3] as a catalyst, the direct alkynylation of thiophenes bearing a variety of substituents has been accomplished by using terminal alkynes as alkynylating reagents. This protocol is also applicable to other electron-rich aromatic heterocycles. dba=dibenzylidenacetone. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3630 / 3633
页数：4
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