Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists

被引：35

作者：

Borza, Istvan ^{[1
]}

Kolok, Sandor ^{[1
]}

Galgoczy, Kornel ^{[1
]}

Gere, Aniko ^{[1
]}

Horvath, Csilla ^{[1
]}

Farkas, Sandor ^{[1
]}

Greiner, Istvan ^{[1
]}

Domany, Gyorgy ^{[1
]}

机构：

[1] Gedeon Richter Chem Works Ltd, H-1475 Budapest 10, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期

关键词：

NR2B antagonist; kynurenic acid amide;

D O I：

10.1016/j.bmcl.2006.10.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：406 / 409

页数：4

共 50 条

[41] Cellular and subcellular distribution of NMDA receptor subunit NR2B in the retina
Pourcho, RG
Qin, P
Goebel, DJ
JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 433 (01) : 75 - 85
[42] Amide-containing NR2B/NMDA receptor antagonists - Pfizer, Inc.: WO2005080317
McCauley, JA
EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (06) : 863 - 870
[43] Regulation of cortical synapse maturation by the NR2B subunit of the NMDA receptor
Hall, B.
Ripley, B.
Ghosh, A.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2006, 24 (08) : 525 - 526
[44] Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
Long-Jun Wu
Min Zhuo
Neurotherapeutics, 2009, 6 : 693 - 702
[45] THE GLUTAMATE NMDA RECEPTOR IN TURTLE RETINA: NR1, NR2A AND NR2B SUBUNITS
Vitanova, Liliya
Kupenova, Petia
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2012, 65 (05): : 683 - 692
[46] Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
McIntyre, Charles J.
McCauley, John A.
Bednar, Bohumil
Bednar, Rodney A.
Butcher, John W.
Claremon, David A.
Cunningham, Michael E.
Freidinger, Roger M.
Gaul, Stanley L.
Homnick, Carl F.
Koblan, Ken S.
Mosser, Scott D.
Romano, Joseph J.
Liverton, Nigel J.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) : 5132 - 5135
[47] Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains
Weed, Michael R.
Bookbinder, Mark
Polino, Joseph
Keavy, Deborah
Cardinal, Rudolf N.
Simmermacher-Mayer, Jean
Cometa, Fu-ni L.
King, Dalton
Thangathirupathy, Srinivasan
Macor, John E.
Bristow, Linda J.
NEUROPSYCHOPHARMACOLOGY, 2016, 41 (02) : 568 - 577
[48] Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors
Schepmann, Dirk
Frehland, Bastian
Lehmkuhl, Kirstin
Tewes, Bastian
Wuensch, Bernhard
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 53 (03) : 603 - 608
[49] Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains
Michael R Weed
Mark Bookbinder
Joseph Polino
Deborah Keavy
Rudolf N Cardinal
Jean Simmermacher-Mayer
Fu-ni L Cometa
Dalton King
Srinivasan Thangathirupathy
John E Macor
Linda J Bristow
Neuropsychopharmacology, 2016, 41 : 568 - 577
[50] Upregulation of NMDA Receptor Subunits NR2A and NR2B in Insular Cortex Following Esophageal Acid Exposure in Rats
Banerjee, Banani
Medda, Bidyut K.
Pochiraju, Soumya
Lang, Ivan M.
Sengupta, Jyoti N.
Shaker, Reza
GASTROENTEROLOGY, 2012, 142 (05) : S551 - S551

← 1 2 3 4 5 →