Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists

被引：35

作者：

Borza, Istvan ^{[1
]}

Kolok, Sandor ^{[1
]}

Galgoczy, Kornel ^{[1
]}

Gere, Aniko ^{[1
]}

Horvath, Csilla ^{[1
]}

Farkas, Sandor ^{[1
]}

Greiner, Istvan ^{[1
]}

Domany, Gyorgy ^{[1
]}

机构：

[1] Gedeon Richter Chem Works Ltd, H-1475 Budapest 10, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期

关键词：

NR2B antagonist; kynurenic acid amide;

D O I：

10.1016/j.bmcl.2006.10.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：406 / 409

页数：4

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