Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis

被引:77
|
作者
Oral, Haluk B. [1 ]
Budak, Ferah
Uzaslan, Esra Kunt
Basturk, Bilkay
Bekar, Ahmet
Akalin, Halls
Ege, Ercument
Ener, Beyza
Goral, Guher
机构
[1] Uluday Univ, Fac Med, Dept Infect Dis & Microbiol, TR-16059 Bursa, Turkey
[2] Uludag Univ, Fac Med, Dept Pulm Dis, TR-16059 Bursa, Turkey
[3] Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey
[4] Uludag Univ, Fac Med, Dept Neurosurg, TR-16059 Bursa, Turkey
关键词
cytokine; genotyping; PCR-SSP; tuberculosis;
D O I
10.1016/j.cyto.2006.07.015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several genes encoding for different cytokines may play crucial roles in host susceptibility to tuberculosis (TB), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of TB was investigated in this study. DNA samples were obtained from a Turkish population of 81 patients with the different clinical forms of TB, and 50 healthy control subjects. All genotyping (IL-6, IL-10, IFN-gamma, TGF-beta and TNF-alpha) experiments were performed using sequence-specific primers PCR (PCR-SSP). Analysis of allete frequencies showed that IL-10 - 1082 G allele frequency was significantly more common in TB patients than healthy controls (37.7% vs 23.0%, p: 0.0 14). No statistically significant differences were observed betwe\en the different clinical forms of the disease. These results suggest that the polymorphisms in IL-10 gene may affect susceptibility to TB and increase risk of developing the disease. To confirm the biological significance of our results, further studies should be performed on other population groups. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:143 / 147
页数:5
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