Maintenance Treatment With Low-Dose Mercaptopurine in Combination With Allopurinol in Children With Acute Lymphoblastic Leukemia and Mercaptopurine-Induced Pancreatitis

被引：25

作者：

Zerra, Patricia ^{[1
]}

Bergsagel, John ^{[1
]}

Keller, Frank G. ^{[1
]}

Lew, Glen ^{[1
]}

Pauly, Melinda ^{[1
]}

机构：

[1] Emory Univ, Childrens Healthcare Atlanta, Aflac Canc Ctr & Blood Disorders Serv, Atlanta, GA 30322 USA

来源：

PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 04期

关键词：

acute lymphoblastic leukemia; allopurinol; mercaptopurine; pancreatitis; 6-MERCAPTOPURINE; TOXICITY; THERAPY; RISK;

D O I：

10.1002/pbc.25841

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mercaptopurine (6-mercaptopurine, 6MP) is a mainstay of curative therapy in childhood acute lymphoblastic leukemia (ALL), and contributes to its 90% overall survival rate. We present two patients with ALL who suffered with severe pancreatitis secondary to 6MP. Through the use of allopurinol in conjunction with reduced dose 6MP, we were able to continue 6MP without further pancreatitis. This report contributes to the small body of literature on 6MP associated pancreatitis in childhood ALL and describes a novel approach to continued use of 6MP during therapy.

引用

页码：712 / 715

页数：4

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