Skin Toxicity Due to Mercaptopurine in Maintenance Therapy Among Children With Acute Lymphoblastic Leukemia

被引：1

作者：

Higgerson, Kayeleigh ^{[1
,2
]}

Flatt, Terrie ^{[1
]}

机构：

[1] Childrens Mercy Hosp, BMT, Dept Pediat Hematol Oncol, Kansas City, MO USA

[2] Childrens Mercy Hosp, 2401 Gillham Rd, Kansas City, MO 64108 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2023年 / 45卷 / 04期

关键词：

mercaptopurine; acute lymphoblastic leukemia; skin toxicity; allopurinol; thiopurine metabolites; 6MMPN; ALLOPURINOL; METABOLITES; 6-MERCAPTOPURINE;

D O I：

10.1097/MPH.0000000000002667

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mercaptopurine is a crucial component in the treatment of acute lymphoblastic leukemia. It is associated with toxicities that can delay treatment. Mercaptopurine is metabolized into 6-thioguanine nucleotides and 6-methylomercaptopurine nucleotides (6MMPN). Accumulation of 6MMPN has previously been associated with hepatotoxicity, pancreatitis, and hypoglycemia. However, skin toxicity has rarely been reported. We report 5 cases of elevated 6MMPN levels associated with cutaneous manifestations.

引用

页码：E514 / E517

页数：4

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