Skin Toxicity Due to Mercaptopurine in Maintenance Therapy Among Children With Acute Lymphoblastic Leukemia

被引：1
|
作者：
Higgerson, Kayeleigh [1 ,2 ]
Flatt, Terrie [1 ]
机构：
[1] Childrens Mercy Hosp, BMT, Dept Pediat Hematol Oncol, Kansas City, MO USA
[2] Childrens Mercy Hosp, 2401 Gillham Rd, Kansas City, MO 64108 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2023年 / 45卷 / 04期
关键词：
mercaptopurine; acute lymphoblastic leukemia; skin toxicity; allopurinol; thiopurine metabolites; 6MMPN; ALLOPURINOL; METABOLITES; 6-MERCAPTOPURINE;
D O I：
10.1097/MPH.0000000000002667
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mercaptopurine is a crucial component in the treatment of acute lymphoblastic leukemia. It is associated with toxicities that can delay treatment. Mercaptopurine is metabolized into 6-thioguanine nucleotides and 6-methylomercaptopurine nucleotides (6MMPN). Accumulation of 6MMPN has previously been associated with hepatotoxicity, pancreatitis, and hypoglycemia. However, skin toxicity has rarely been reported. We report 5 cases of elevated 6MMPN levels associated with cutaneous manifestations.
引用
收藏
页码：E514 / E517
页数：4
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