Tim-4 in Health and Disease: Friend or Foe?

被引：33

作者：

Liu, Wen ^{[1
]}

Xu, Liyun ^{[1
,2
]}

Liang, Xiaohong ^{[1
]}

Liu, Xiaojun ^{[3
]}

Zhao, Yangbing ^{[3
,4
]}

Ma, Chunhong ^{[1
]}

Gao, Lifen ^{[1
]}

机构：

[1] Shandong Univ, Sch Basic Med Sci, Dept Immunol, Key Lab Expt Teratol,Minist Educ,Shandong Prov Ke, Jinan, Peoples R China

[2] Zhoushan Hosp, Cell & Mol Biol Lab, Zhoushan, Peoples R China

[3] Univ Penn, Ctr Canc, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

Tim-4; macrophages; T cells; phosphatidylserine; immune regulation; T-CELL IMMUNOGLOBULIN; DOMAIN-CONTAINING MOLECULE-4; PHOSPHATIDYLSERINE RECEPTOR TIM-4; RHEUMATOID-ARTHRITIS; CHINESE HAN; INCREASED EXPRESSION; APOPTOTIC CELLS; GENE; TUMOR; ASSOCIATION;

D O I：

10.3389/fimmu.2020.00537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is a phosphatidylserine receptor and is selectively expressed on antigen presenting cells. Recently, Tim-4 was reported to be expressed on iNKT cells, B1 cells, and tumor cells, suggesting it has multiple biological functions. In this review, we mainly summarize the expression and regulation of Tim-4 in immune cells including T cells, macrophages, dendritic cells, NKT cells, B cells, and mast cells. The expression of Tim-4 in these cells implies that Tim-4 might participate in immune related diseases. Emerging evidence emphasizes a substantial role for Tim-4 in maintaining homeostasis by regulating various immune responses, including viral infection, allergy, autoimmunity, and tumor immunity. Here, we collectively evaluated the role of Tim-4 in health and diseases. This summary will be extremely useful to fully understand the function of Tim-4 in the pathogenesis of immune related diseases, which would provide novel clues for the diagnosis and treatment of diseases.

引用

页数：10

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