Synthesis of the 3,5,3′,5′-3H4-2,2′-diphenylene-iodonium cation and of its 4-nitro derivative

被引：0
|
作者：
Berthon, JL
Dias, M
Mornet, R
Camadro, JM
机构：
[1] Fac Sci, Lab Ingn Mol & Mat Organ, F-49045 Angers, France
[2] Inst Jacques Monod, Lab Ingn Prot & Controle Metab, F-75251 Paris 05, France
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 05期
关键词：
diphenyleneiodonium; DPI; synthesis; tritium labelling; enzyme inhibition;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The 3,5,3',5'-H-3(4)-2,2'-diphenyleneiodonium cation [H-3]-1 was synthesized in three steps from cold 2,2' -diaminodiphenyl. The nitration of [H-3]-1 gave easily the 4-nitro derivative [H-3]-2 These two compounds which contain four tritium labels were obtained with a high specific activity, and are proposed as tools to study the interaction of 2,2'-diphenyleneiodonium cations with redox enzymes, especially flavoproteins.
引用
收藏
页码：515 / 522
页数：8
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