Synthesis of the 3,5,3′,5′-3H4-2,2′-diphenylene-iodonium cation and of its 4-nitro derivative

被引：0

作者：

Berthon, JL

Dias, M

Mornet, R

Camadro, JM

机构：

[1] Fac Sci, Lab Ingn Mol & Mat Organ, F-49045 Angers, France

[2] Inst Jacques Monod, Lab Ingn Prot & Controle Metab, F-75251 Paris 05, France

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 05期

关键词：

diphenyleneiodonium; DPI; synthesis; tritium labelling; enzyme inhibition;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3,5,3',5'-H-3(4)-2,2'-diphenyleneiodonium cation [H-3]-1 was synthesized in three steps from cold 2,2' -diaminodiphenyl. The nitration of [H-3]-1 gave easily the 4-nitro derivative [H-3]-2 These two compounds which contain four tritium labels were obtained with a high specific activity, and are proposed as tools to study the interaction of 2,2'-diphenyleneiodonium cations with redox enzymes, especially flavoproteins.

引用

页码：515 / 522

页数：8

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