Nornostocine congeners as potential anticancer drugs: An overview

被引：13
|
作者：
Sahoo, Chita R. [1 ,2 ,3 ]
Paidesetty, Sudhir K. [3 ]
Padhy, Rabindra N. [1 ,2 ]
机构：
[1] Siksha O Anusandhan Deemed Be Univ, Inst Med Sci, Cent Res Lab, Bhubaneswar 751003, Odisha, India
[2] Siksha O Anusandhan Deemed Be Univ, Sum Hosp, Bhubaneswar 751003, Odisha, India
[3] Siksha O Anusandhan Deemed Be Univ, Sch Pharmaceut Sci, Dept Med Chem, Bhubaneswar 751003, Odisha, India
来源：
DRUG DEVELOPMENT RESEARCH | 2019年 / 80卷 / 07期
关键词：
antiproliferation; cyanobacteria; pyrazolo[4; 3-e][1; 2; 4] triazole; SAR; SILDENAFIL ANALOGS; NOSTOCINE-A; SULFONAMIDES; TYROSINASE;
D O I：
10.1002/ddr.21577
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The naturally occurring phyco-constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with a remarkable anticancer activity. This review summarizes the chemistry of numerous synthetic strategies of demethylated nostocine as "nornostocine derivatives," in which the substitutes are connected to a few functionalities with the pyrazolotriazine moiety at N-1, C-3, and C-5 positions. These strategies may provide a framework to design and develop a novel potent anticancer drug candidate(s) with an augment of structure activity relationship related to anticancer activities.
引用
收藏
页码：878 / 892
页数：15
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