Hydroxamic acid hybrids as the potential anticancer agents: An Overview

被引：32
|
作者：
Liu, Wenhua [1 ]
Liang, Yuchen [2 ]
Si, Xiaoyong [3 ]
机构：
[1] Henan Univ, Huaihe Hosp, Dept Psychol & Mental Hlth, Kaifeng 475000, Henan, Peoples R China
[2] Sichuan Univ, Coll Life Sci, Chengdu 610064, Sichuan, Peoples R China
[3] Shaoxing Univ, Zhuji Affiliated Hosp, Dept Gen Practice, Shaoxing, Zhejiang, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 205卷
关键词：
Hydroxamic acid; Hybrid compounds; Anticancer; Drug resistance; Mechanism of action; Structure-activity relationship; HISTONE DEACETYLASE INHIBITORS; ACTIVITY IN-VITRO; BIOLOGICAL EVALUATION; HDAC INHIBITORS; ANTITUMOR-ACTIVITY; EVODIAMINE DERIVATIVES; N-HYDROXYPROPENAMIDES; DUAL INHIBITORS; TOPOISOMERASE-I; CANCER-CELLS;
D O I：
10.1016/j.ejmech.2020.112679
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hydroxamic acid derivatives are potential histone deacetylase inhibitors, and several hydroxamic acidbased histone deacetylase inhibitors have already been used clinically as potent anticancer agents, so hydroxamic acid derivatives are useful scaffolds for the development of novel anticancer agents. Hybridization of hydroxamic acid moiety with other anticancer pharmacophores can overcome drug resistance and improve the specificity, so rational design of hydroxamic acid hybrids may provide valuable therapeutic interventions for the treatment of cancers. The purpose of the present review article is to update the current developments in hydroxamic acid hybrids with an emphasis on anticancer activity, structure-activity relationships, and mechanisms of action. (C) 2020 Elsevier Masson SAS. All rights reserved.
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页数：26
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